ValidRx PolyCheck IV Compat — IV Compatibility Reference

IV Medications (up to 6)

Diluents / IV Fluids

Administration Route

Calculate the osmolarity of any IV admixture. Add the base solution and any drug additives to see the total osmolarity in mOsm/L — automatically classified as hypo-, iso-, or hyperosmolar. Guides peripheral vs central line selection.

Base IV Solution

mL

Drug Additives

📊 Common IV Solution Osmolarity Quick Reference

Values in mOsm/L · Theoretical osmolarity = Σ(concentration × dissociation particles) · Measured osmolality may differ slightly · Source: Gahart 2024 · ASHP Injectable Drug Information

💊 Carboplatin Dose Calculator — Calvert Formula

Dose (mg) = Target AUC × (GFR + 25) · Calvert AH et al. J Clin Oncol 1989 · GFR by Cockcroft-Gault or measured

Patient Age (years) *

Sex *

Weight

Height

Serum Creatinine (mg/dL) *

Target AUC (mg·min/mL) *

GFR Method

BSA-based max dose cap

⚠️ Clinical Reminders:
• The Calvert formula uses actual GFR, not BSA-normalized GFR. If an eGFR (normalized to 1.73m²) is used, de-normalize: GFR = eGFR × BSA / 1.73
• FDA 2010 label update: cap GFR at 125 mL/min to prevent overdosing (Vermorken cap)
• For elderly or cachectic patients: use actual weight; for obese patients: use IBW or adjusted BW for Cockcroft-Gault
• Round to nearest 50mg if dose >300mg, nearest 25mg if 100–300mg
• Carboplatin is a vesicant — confirm line patency before infusion
• Source: Calvert AH et al. J Clin Oncol 1989 · FDA 2010 · ASCO Guidelines

🧪 IV Compounding & Serial Dilution Calculator

Calculate volumes needed to compound any target concentration from two source solutions using the Alligation method (C₁V₁ + C₂V₂ = C₃V₃)

Solution A — Concentration *

Solution B — Concentration *

Target Concentration *

Total Volume Needed (mL) *

Or leave blank to calculate minimum required volume

Quick presets:

⚠️ Compounding Reminders:
• Verify osmolarity of final solution before infusion (3% NaCl ≈ 1026 mOsm/L — central line required)
• 23.4% NaCl must be drawn up carefully — fatal if given undiluted; label bag prominently
• Hypertonic dextrose solutions (>12.5%) require central venous access
• All compounded solutions must be clearly labeled: drug, concentration, volume, date/time, expiry, pharmacist
• USP 797 guidelines apply to all sterile compounding

⚡ Weight-Based Continuous Infusion Rate Calculator

Calculate mL/hr from mcg/kg/min, units/kg/hr, or mg/kg/hr for any weight-based continuous infusion

Drug / Agent

Patient Weight

Use actual body weight (ABW) unless specified

Ordered Dose Rate

Drug Concentration in Bag

🎗️ Oncology Dose Calculator — BSA & Weight-Based

NCCN-referenced dosing · Mosteller BSA · Supports flat-dose, mg/kg, and mg/m² regimens · Always verify against current protocol and institutional SOPs

Patient Weight

Height

Sex

Agent / Regimen

Dose Reduction (%)

Capping Rule (BSA)

⚠️ Oncology Dosing Safety Reminders:
• All doses must be verified against the current NCCN guidelines, institutional protocol, and clinical trial data before administration
• Vincristine: CAP at 2mg absolute (regardless of BSA) — fatal overdose risk
• Bleomycin: cumulative lifetime cap 360 units — track all prior doses
• Doxorubicin: cumulative lifetime cap 450-550 mg/m² — verify prior anthracycline exposure
• High-dose methotrexate requires leucovorin rescue, aggressive hydration, urine alkalinization (pH >7.0), and serial MTX levels
• For obese patients (BMI >30): consider using actual body weight for most agents per ASCO 2012 guideline; discuss with oncologist
• Sources: NCCN Clinical Practice Guidelines · Lexicomp Oncology Drug Information · Micromedex · ASCO 2012 Chemotherapy Dosing

🧒 Neonatal & Pediatric Dose Calculator

Weight-based and BSA-based dosing · Neofax · Lexicomp Pediatrics · AAP Red Book · Always verify against current protocol and patient-specific factors

Patient Age

Weight

Height / Length (cm)

Sex

Drug / Category

Route / Indication

⚠️ Pediatric Dosing Safety Reminders:
• Always verify dose, frequency, and route against Neofax, Lexicomp Pediatrics, or AAP Red Book
• Neonatal PMA/PNA significantly affects drug clearance — adjust dose and frequency for prematurity
• Maximum single dose and maximum daily dose caps apply — check before rounding up
• Gentamicin neonatal dosing: once-daily extended interval per PMA — check institution NICU protocol
• Renal and hepatic function affect neonatal drug clearance significantly more than older children
• Weight must be current (within 24H for neonates) — growth changes rapidly in the first weeks

💉 Vancomycin AUC-Guided Dosing

ASHP/IDSA/SIDP 2020 Consensus — Population PK initial dosing + Patient-specific PK adjustment from trough levels. AUC₁₅/MIC target: 400–600 mg·h/L

⚠️ HIGH ALERT MEDICATION — Verify all doses independently. Obtain levels at steady state (≥3–4 doses). This tool supports but does not replace clinical judgment.

Patient Demographics & Clinical Status

Age (years) *

Sex *

Actual Body Weight (kg) *

Height (inches)

e.g. 5'7" = 67 inches

Serum Creatinine (mg/dL) *

Clinical Population

Indication / Condition

MIC (mg/L)

Infusion Duration

Population PK References (ASHP 2020):
CL = 0.00083 × CrCl × Weight (L/hr) • Vd varies by population (0.4–1.0 L/kg)
Loading dose: 20–35 mg/kg IBW/ABW ×1 (max 3,000 mg) for serious infections
AUC₁₅/MIC target: 400–600 (MIC ≤1 mg/L) • CNS: AUC 600 preferred

🎯 AUC Targets by Indication

MRSA bacteremia / serious: 400–600
MRSA pneumonia / VAP: 400–600
CNS infection / meningitis: 500–600
Endocarditis: 400–600
Osteomyelitis: 400–600
Empiric / SSTI: 400–500
MIC = 2 mg/L: Consider alternative agent

📈 Population Vd by Status

Standard adult: 0.5–0.7 L/kg
ICU / critically ill: 0.7–0.9 L/kg (fluid shifts)
Obese (BMI 30–40): 0.65 L/kg ABW
Morbidly obese (BMI >40): AdjBW = IBW + 0.4(TBW−IBW)
Burns (>20% TBSA): 0.8–1.0 L/kg
Cystic fibrosis: 0.3–0.5 L/kg
Elderly (≥65): 0.5 L/kg (reduced muscle mass)

💉 Loading Dose Guidance

Standard: 25 mg/kg ABW × 1 (max 3,000 mg)
Seriously ill / ICU: 30–35 mg/kg (max 3,000 mg)
Infuse at ≤1,000 mg/hr to prevent Red Man Syndrome
Loading dose before first maintenance dose
Separate infusion; do NOT include in maintenance interval calculation

⚠ Nephrotoxicity & Monitoring

AUC >600 → nephrotoxicity risk increases
Trough >20 mg/L → HIGH nephrotoxicity risk
Draw trough at steady state (≥3–4 doses)
Peak levels are NOT routinely recommended per ASHP 2020 — AUC-guided monitoring uses trough only or two elimination-phase levels
Recheck SCr every 48–72H during therapy
Avoid concurrent nephrotoxins (aminoglycosides, NSAIDs, contrast)
ASHP 2020: AUC monitoring reduces nephrotoxicity 35% vs trough-only

📋 Red Man Syndrome Prevention

Infuse at ≤500 mg/30 min (i.e. max 1,000 mg/hr) • Dilute to ≤5 mg/mL
Doses 1–1.5g: infuse over 60 min • Doses 1.5–2.5g: infuse over 90–120 min • Doses >2.5g: infuse over 150–180 min
If RMS occurs: stop infusion, give diphenhydramine 25–50 mg IV, resume at slower rate after resolution

🏠 Special Populations

HD: Give post-dialysis (3–5 mg/kg per session), recheck level pre-next session (target 15–20 mg/L pre-HD)
CRRT: CL ≈ 10–30 mL/min depending on modality; dose Q12–24H, monitor AUC closely
Pediatric: 15 mg/kg Q6H (neonates Q12H); target AUC 400–600
Source: ASHP/IDSA/SIDP 2020 • Rybak MJ AJHP 2020

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🩸 Iron Deficiency Replacement Calculator

Oral and IV iron dosing · Ganzoni formula · Ferinject / Venofer / Injectafer · BSH 2021 · KDIGO 2024

Weight (kg) *

Current Hgb (g/dL) *

Target Hgb (g/dL)

Serum Ferritin (ng/mL)

Transferrin Saturation (%)

Population

Route Preference

IV Product

⚠️ Clinical Notes: IV iron dextran: test dose 25mg over 15 min, observe 60 min before full infusion. Ferric carboxymaltose: max 750mg/dose (1000mg if ≥50kg, EU label). Iron sucrose: max 200mg/infusion dialysis; 300-500mg slow infusion non-dialysis. CKD targets: non-dialysis ferritin >100, TSAT >20%; HD ferritin 200-500, TSAT 30-50%. Oral iron: every-other-day dosing improves absorption vs daily (hepcidin suppression — Moretti 2015). Sources: BSH IDA 2021 · KDIGO Anemia 2024 · Ganzoni AM Schweiz Med Wochenschr 1970.

🧪 TPN / Parenteral Nutrition Calculator

Caloric needs · Macronutrients · Electrolytes · Osmolarity · Ca/PO₄ compatibility · ASPEN 2022 · Infants & Adults

Population

Weight (kg) *

Height (cm)

Sex

Stress Factor

Total PN Volume/Day (mL)

Dextrose % (final)

Amino Acids % (final)

IVFE (Lipid) g/day

Electrolytes per Day

Sodium (mEq)

Potassium (mEq)

Calcium gluconate (mEq)

Phosphate (mmol)

Magnesium (mEq)

⚠️ Ca/PO₄ Compatibility: Product >65 (mEq/L Ca × mmol/L PO₄) → precipitation risk — FATAL if infused as precipitate. Neonates most vulnerable. Reduce one or both electrolytes, or use a 2-in-1 PN + separate IVFE. Central line required for osmolarity >900 mOsm/L (peripheral max 600-900). All TPN must be verified by a pharmacist before compounding. Sources: ASPEN 2022 · Driscoll DF 2009 Ca/PO₄ guideline · Trissel's Handbook on Injectable Drugs.

⚗️ β-Lactam PK/PD Calculator — %T>MIC

Time-dependent killing · %fT>MIC optimization · Intermittent / Extended / Continuous infusion · Penicillins · Cephalosporins · Carbapenems

Drug

Dose (mg)

Infusion Strategy

Dosing Interval (H)

MIC (mg/L)

Weight (kg)

CrCl (mL/min)

Target %T>MIC

PK/PD: β-Lactams are time-dependent — efficacy = %fT>MIC (free drug above MIC). Extended infusion (3-4H) increases T>MIC without changing dose. Continuous infusion achieves 100% T>MIC with Css=Dose/CL — optimal for MIC at breakpoint. Sources: IDSA ESKAPE · Roberts JA Clin Infect Dis 2014 · EUCAST PK/PD.

🎯 Aminoglycoside PK/PD Calculator

Peak/MIC ≥10:1 target (MIC ≤1 only) · Trough <0.5 mg/L (last 4H cycle) · Loading + Maintenance · Sawchuk-Zaske · Hartford nomogram · Moore RD 1987

Drug

Strategy

Weight (kg)

Height (inches)

Sex

Age (years)

Serum Creatinine (mg/dL)

MIC (mg/L) — MUST be ≤1

Population

Trough-Based Dose Adjustment (Optional)

Enter a trough level to calculate patient-specific ke, t½, and adjust interval. Peak levels are NOT required.

Current Dose (mg)

Current Interval (hr)

Observed Trough (mg/L)

Draw in last 4H of cycle (30 min pre-dose)

Trough drawn at (hr after infusion START)

e.g. Q24H with 30-min infusion: enter 23.5